3-Alkanoyl-5-hydroxymethyl tetronic acid homologues and resistomycin: new inhibitors of HIV-1 protease. I. Fermentation, isolation and biological activity.
نویسندگان
چکیده
In the course of a screening program for HIV-1 protease inhibiting activity, six new homologues of 3-alkanoyl-5-hydroxymethyl tetronic acids (1 approximately 6) and the known natural product resistomycin (7) were isolated from cultures of the Actinomycete strain DSM 7357. The substituted tetronic acids belong to a recently described structural class of secondary metabolites. The HIV-1 activity of resistomycin (7) has not been reported before.
منابع مشابه
3-Alkanoyl-5-hydroxymethyl tetronic acid homologues: new inhibitors of HIV-1 protease. II. Structure determination.
Six new homologues of the 3-alkanoyl-5-hydroxymethyl tetronic acid (1 ~6) (Scheme 1) have been identified in extracts of the Actinomycete strain DSM7357 as inhibitors of HIV-1 protease. In the preceding paper1} we described the fermentation, isolation and biological properties of these secondary metabolites 1 ~6. The length and substitution pattern of the alkanoyl side chain of the tetronic aci...
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عنوان ژورنال:
- The Journal of antibiotics
دوره 47 2 شماره
صفحات -
تاریخ انتشار 1994